ANTIBODY-MEDIATED DELIVERY OF A VIRAL MHC-I EPITOPE INTO THE CYTOSOL OF TARGET TUMOR CELLS REPURPOSES VIRUS-SPECIFIC CD8+ T CELLS FOR CANCER IMMUNOTHERAPY

Abstract Background Redirecting pre-existing virus-specific Intermediate cytotoxic CD8+ T lymphocytes (CTLs) to tumors by simulating a viral infection of the tumor cells has great potential for cancer immunotherapy.However, this strategy is limited by lack of amenable method for viral antigen delivery into the cytosol of target tumors.Here, we addr

Bauxite ore open-pit mining activities are conducted in spread areas and increase the potential for water pollution, implying a need for Mounts good management.GeoWEPP is a spatial model that predicts the erosion magnitude and the location of sedimentation.This helps in erosion management and control, including constructing a settling pond.Therefor

The existence of Law No.40/2007 concerning Limited Liability Company (or UU PT) in Indonesia can be an external motivation of the companies to ensure the conduct of corporate social responsibility (CSR) activities.In addition, the internal factor of the company PLATINUM 100% CREATINE can both drive and inhibit the conduct of CSR activities, such as

The ability to properly assess and accurately phenotype true differences in feed efficiency among dairy cows is key to the development of breeding programs for improving feed efficiency.The variability among individuals in feed efficiency is commonly characterised by the residual intake approach.Residual feed intake is represented by the residuals